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This Vax’s Success Hinges on Trust

28 Feb 2026
2 min

Cervical Cancer and HPV Vaccination in India

Cervical cancer is a significant public health issue in India, being the second most common cancer among women and responsible for over 42,000 deaths annually.

HPV Vaccine Introduction

  • The Government of India (GoI) has initiated a 90-day rollout of a single-dose human papillomavirus (HPV) vaccine, targeting 14-year-old girls.
  • This move is a critical intervention for public health, though it faces challenges even before its implementation.

Challenges and Resistance

  • There is a global pattern of scepticism concerning HPV vaccination efforts.
  • WHO and oncologists support the vaccine's effectiveness in cancer prevention, yet skepticism remains due to: 
    • Concerns about long-term safety data.
    • Perceived influence of the pharmaceutical sector on policy decisions.
    • Doubts about the robustness of post-vaccination monitoring.
  • Historical controversies, such as the 2009 clinical trial in India that faced ethical scrutiny and was suspended, affect public perception.
  • Instances from Japan, Europe, and Africa show hesitancy following reports of adverse effects.

Voluntary Vaccination and Liability Concerns

  • The decision to make the vaccine voluntary adds complexity, as the state's liability in adverse outcomes may be limited, similar to the Covid vaccination scenario.
  • Informed consent issues arise, complicating potential claims.

Success Factors

  • The effectiveness of the HPV vaccination drive hinges on: 
    • Building public trust through transparent communication.
    • Implementing rigorous safety monitoring.
    • Focusing on rural areas where health literacy is uneven.

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Health Literacy

The degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions. AI integration aims to improve this, especially at the community level.

Informed Consent

A patient's voluntary agreement to a medical procedure after being fully informed of its nature, purpose, risks, benefits, and alternatives. The article highlights that consent is invalid if it's based on inadequate information about unproven treatments.

Adverse Effects

Unwanted or harmful reactions that occur following the administration of a drug or vaccine. While rare, reports of adverse effects can contribute to vaccine hesitancy.

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