RNA-based antiviral offers strong defence against deadly agri virus | Current Affairs | Vision IAS

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RNA-based antiviral offers strong defence against deadly agri virus

2 min read

Plant Virus Challenge and Economic Impact

Plant viruses represent a significant threat to agriculture, affecting over 1,200 plant species and critical food crops such as cucumbers, squash, and cereals. According to the U.N. Food and Agriculture Organisation (FAO), nearly 40% of the world's annual crop yield suffers from plant pests and diseases, with plant viruses alone causing over $30 billion in losses each year.

RNA-Based Antiviral Technology

Scientists are leveraging RNA-based technologies to enhance plant defenses against viruses, akin to how human immune systems combat viral infections. Researchers at Martin Luther University Halle-Wittenberg have developed an RNA-based antiviral agent to protect against the cucumber mosaic virus (CMV), a destructive virus affecting multiple plant species.

Mechanism of RNA Silencing

  • When a virus infects a plant, it introduces double-stranded RNA (dsRNA).
  • The plant's immune system activates Dicer-like enzymes (DCLs) to cut dsRNA into small interfering RNAs (siRNAs).
  • These siRNAs help recognize and eliminate viral RNA, although the process isn't always efficient due to viral mutations.

RNA-Based Protection Techniques

Host-Induced Gene Silencing (HIGS)

  • Plants are genetically modified to produce virus-fighting dsRNA internally.
  • Challenges: Regulatory, cost, and viral resistance issues limit HIGS adoption.

Spray-Induced Gene Silencing (SIGS)

  • RNA sprays are applied to plants, triggering immune responses.
  • Advantages: Cost-effective, environmentally friendly, and no genetic modification needed.
  • Limitation: Traditional dsRNA formulations often produce ineffective siRNAs.

Innovative RNA-Based Approach

  • Researchers engineered "effective dsRNA" enriched with potent siRNAs to enhance antiviral responses.
  • Laboratory tests on Nicotiana benthamiana showed up to 80% reduction in viral load.
  • Key advantages include precision targetting, stronger defense, and adaptability to new strains.

Challenges and Future Prospects

  • Environmental Stability: RNA degrades quickly; solutions like nanoparticle delivery systems are under exploration.
  • Cost and Scalability: Production costs are decreasing, but large-scale use remains costly.
  • Regulatory Approvals: Approval processes vary by country; the US EPA approved the first RNA-based product in 2023.

The research shows promise for RNA-based technology to combat other plant viruses and potentially fungal, bacterial diseases, and insect pests, with ongoing efforts to improve real-world application and effectiveness.

  • Tags :
  • Plant Virus Challenge
  • RNA-Based Antiviral Technology
  • RNA Silencing
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